Glucocorticoid- and pioglitazone-induced proteinuria reduction in experimental NS both correlate with glomerular ECM modulation

Glucocorticoid- and pioglitazone-induced proteinuria reduction in experimental NS both correlate with glomerular ECM modulation

Summary: Idiopathic nephrotic syndrome (NS) is a common glomerular disease. Although glucocorticoids (GC) are the primary treatment, the PPARγ agonist pioglitazone (Pio) also reduces proteinuria in patients with NS and directly protects podocytes from injury. Because both drugs reduce proteinuria, w...

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Bibliographic Details
Main Authors: Sagar Bhayana, Julie A. Dougherty, Yu Kamigaki, Shipra Agrawal, Saranga Wijeratne, James Fitch, Amanda P. Waller, Katelyn J. Wolfgang, Peter White, Bryce A. Kerlin, William E. Smoyer
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Nephrology
Gene network
Systems biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223027086

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http://www.sciencedirect.com/science/article/pii/S2589004223027086

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