Automated synthesis of 18F radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry

Automated synthesis of 18F radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry

Abstract Background Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing. We aimed to develop a radiolabelled form of Oncrasin-1 to enable in-vivo imaging of mutant KRAS expression in malignant tumours. T...

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Bibliographic Details
Main Authors: Alexander F. McDonald, Yit Wooi Goh, Jonathan M. White, Andrew M. Scott, Uwe Ackermann
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Radiofluorination
18F fluorination
Automated synthesis
Oncology
Tracer development
Iodonium salt
Online Access:http://link.springer.com/article/10.1186/s41181-020-00104-x

Internet

http://link.springer.com/article/10.1186/s41181-020-00104-x

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