Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer

Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer

IntroductionTriple-negative breast cancer (TNBC) comprises a heterogeneous group of clinically aggressive tumors with high risk of recurrence and metastasis. Current pharmacological treatment options remain largely limited to chemotherapy. Despite promising results, the efficacy of immunotherapy and...

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Main Authors: Fokhrul Hossain, Deniz A. Ucar, Giulia Monticone, Yong Ran, Samarpan Majumder, Kristina Larter, Hanh Luu, Dorota Wyczechowska, Soroor Heidari, Keli Xu, Sudarvili Shanthalingam, Margarite Matossian, Yaguang Xi, Matthew Burow, Bridgette Collins-Burow, Luis Del Valle, Chindo Hicks, Jovanny Zabaleta, Todd Golde, Barbara Osborne, Lucio Miele
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
triple-negative breast cancer
sulindac sulfide
immunotherapy
Notch
T-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1244159/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1244159/full

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