Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications
Head and neck cancer (HNC) is one of the most common cancers in the world according to GLOBCAN. In 2018, it was reported that HNC accounts for approximately 3% of all human cancers (51,540 new cases) and is the cause of nearly 1.5% of all cancer deaths (10,030 deaths). Despite great advances in trea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/531 |
| _version_ | 1797485597193928704 |
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| author | Katarzyna Starska-Kowarska |
| author_facet | Katarzyna Starska-Kowarska |
| author_sort | Katarzyna Starska-Kowarska |
| collection | DOAJ |
| description | Head and neck cancer (HNC) is one of the most common cancers in the world according to GLOBCAN. In 2018, it was reported that HNC accounts for approximately 3% of all human cancers (51,540 new cases) and is the cause of nearly 1.5% of all cancer deaths (10,030 deaths). Despite great advances in treatment, HNC is indicated as a leading cause of death worldwide. In addition to having a positive impact on general health, a diet rich in carotenoids can regulate stages in the course of carcinogenesis; indeed, strong epidemiological associations exist between dietary carotenoids and HNS, and it is presumed that diets with carotenoids can even reduce cancer risk. They have also been proposed as potential chemotherapeutic agents and substances used in chemoprevention of HNC. The present review discusses the links between dietary carotenoids and HNC. It examines the prospective anticancer effect of dietary carotenoids against intracellular cell signalling and mechanisms, oxidative stress regulation, as well as their impact on apoptosis, cell cycle progression, cell proliferation, angiogenesis, metastasis, and chemoprevention; it also provides an overview of the limited preclinical and clinical research published in this arena. Recent epidemiological, key opinion-forming systematic reviews, cross-sectional, longitudinal, prospective, and interventional studies based on in vitro and animal models of HNC also indicate that high carotenoid content obtained from daily supplementation has positive effects on the initiation, promotion, and progression of HNC. This article presents these results according to their increasing clinical credibility. |
| first_indexed | 2024-03-09T23:21:55Z |
| format | Article |
| id | doaj.art-04b7e24998af4f8fa90c36c9544e0ca3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:21:55Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-04b7e24998af4f8fa90c36c9544e0ca32023-11-23T17:25:18ZengMDPI AGNutrients2072-66432022-01-0114353110.3390/nu14030531Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical ImplicationsKatarzyna Starska-Kowarska0Department of Physiology, Pathophysiology and Clinical Immunology, Department of Clinical Physiology, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Lodz, PolandHead and neck cancer (HNC) is one of the most common cancers in the world according to GLOBCAN. In 2018, it was reported that HNC accounts for approximately 3% of all human cancers (51,540 new cases) and is the cause of nearly 1.5% of all cancer deaths (10,030 deaths). Despite great advances in treatment, HNC is indicated as a leading cause of death worldwide. In addition to having a positive impact on general health, a diet rich in carotenoids can regulate stages in the course of carcinogenesis; indeed, strong epidemiological associations exist between dietary carotenoids and HNS, and it is presumed that diets with carotenoids can even reduce cancer risk. They have also been proposed as potential chemotherapeutic agents and substances used in chemoprevention of HNC. The present review discusses the links between dietary carotenoids and HNC. It examines the prospective anticancer effect of dietary carotenoids against intracellular cell signalling and mechanisms, oxidative stress regulation, as well as their impact on apoptosis, cell cycle progression, cell proliferation, angiogenesis, metastasis, and chemoprevention; it also provides an overview of the limited preclinical and clinical research published in this arena. Recent epidemiological, key opinion-forming systematic reviews, cross-sectional, longitudinal, prospective, and interventional studies based on in vitro and animal models of HNC also indicate that high carotenoid content obtained from daily supplementation has positive effects on the initiation, promotion, and progression of HNC. This article presents these results according to their increasing clinical credibility.https://www.mdpi.com/2072-6643/14/3/531head and neck cancer (HNC)carotenoids (CTDs)cellular signallingcell cycle progressionapoptosischemoprevention |
| spellingShingle | Katarzyna Starska-Kowarska Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications Nutrients head and neck cancer (HNC) carotenoids (CTDs) cellular signalling cell cycle progression apoptosis chemoprevention |
| title | Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications |
| title_full | Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications |
| title_fullStr | Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications |
| title_full_unstemmed | Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications |
| title_short | Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications |
| title_sort | dietary carotenoids in head and neck cancer molecular and clinical implications |
| topic | head and neck cancer (HNC) carotenoids (CTDs) cellular signalling cell cycle progression apoptosis chemoprevention |
| url | https://www.mdpi.com/2072-6643/14/3/531 |
| work_keys_str_mv | AT katarzynastarskakowarska dietarycarotenoidsinheadandneckcancermolecularandclinicalimplications |