MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to inv...

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Bibliographic Details
Main Authors: Robin Ferrari, Gaëlle Martin, Oya Tagit, Alan Guichard, Alessandra Cambi, Raphaël Voituriez, Stéphane Vassilopoulos, Philippe Chavrier
Format: Article
Language:English
Published: Nature Portfolio 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12930-y

Internet

https://doi.org/10.1038/s41467-019-12930-y

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