Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wn...

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Bibliographic Details
Main Authors: Kenneth C. Valkenburg, Carrie R. Graveel, Cassandra R. Zylstra-Diegel, Zhendong Zhong, Bart O. Williams
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:Cancers
Subjects:
Wnt
β-catenin
stem cells
cancer stem cells
colon
mammary
prostate
therapeutics
Online Access:http://www.mdpi.com/2072-6694/3/2/2050/

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