DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features

DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features

Chromosomal abnormalities are detected in 20–30% of patients with chronic myelomonocytic leukemia (CMML) and correlate with prognosis. On the mutation level, disruptive alterations are particularly frequent in chromatin regulatory genes. However, little is known about the consequential alterations i...

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Bibliographic Details
Main Authors: Laura Palomo, Roberto Malinverni, Marta Cabezón, Blanca Xicoy, Montserrat Arnan, Rosa Coll, Helena Pomares, Olga García, Francisco Fuster-Tormo, Javier Grau, Evarist Feliu, Francesc Solé, Marcus Buschbeck, Lurdes Zamora
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Epigenetics
Subjects:
chronic myelomonocytic leukemia
dna methylation
hypermethylation
prognosis
tet2
Online Access:http://dx.doi.org/10.1080/15592294.2017.1405199

Internet

http://dx.doi.org/10.1080/15592294.2017.1405199

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