<i>HTRA1</i> Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid

<i>HTRA1</i> Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid

High-temperature requirement A1 (HtrA1) has been identified as a disease-susceptibility gene for age-related macular degeneration (AMD) including polypoidal choroidal neovasculopathy (PCV). We characterized the underlying phenotypic changes of transgenic (Tg) mice expressing ubiquitous CAG promoter...

Full description

Bibliographic Details
Main Authors: Waseem Ahamed, Richard Ming Chuan Yu, Yang Pan, Takeshi Iwata, Veluchamy Amutha Barathi, Yeo Sia Wey, Sai Bo Bo Tun, Beiying Qiu, Alison Tan, Xiaomeng Wang, Chui Ming Gemmy Cheung, Tien Yin Wong, Yasuo Yanagi
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
HtrA1 mice
age-related macular degeneration
polypoidal choroidal neovascularization
RNA-sequencing
subclinical inflammation
proangiogenic response
Online Access:https://www.mdpi.com/1422-0067/23/18/10206

Internet

https://www.mdpi.com/1422-0067/23/18/10206

Similar Items