Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure

Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure

Neferine (Nef) might possess anti-depressive properties; however, its therapeutic effects are yet to be elucidated. Therefore, in this study, we aimed to explore the anti-depressant property of Nef using a mouse model of chronic stress-induced depression. Fifteen depression-prone mice were randomly...

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Bibliographic Details
Main Authors: Zaiquan Dong, Qinglian Xie, Feiyu Xu, Xiaoling Shen, Yanni Hao, Jin Li, Haizhen Xu, Qiang Peng, Weihong Kuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
neferine
anti-depressant
chronic mild stress
intestinal flora
Lactobacillus
monoamine neurotransmitters
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.974949/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.974949/full

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