Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure

Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure

Neferine (Nef) might possess anti-depressive properties; however, its therapeutic effects are yet to be elucidated. Therefore, in this study, we aimed to explore the anti-depressant property of Nef using a mouse model of chronic stress-induced depression. Fifteen depression-prone mice were randomly...

Full description

Bibliographic Details
Main Authors:	Zaiquan Dong, Qinglian Xie, Feiyu Xu, Xiaoling Shen, Yanni Hao, Jin Li, Haizhen Xu, Qiang Peng, Weihong Kuang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Series:	Frontiers in Pharmacology
Subjects:	neferine anti-depressant chronic mild stress intestinal flora Lactobacillus monoamine neurotransmitters
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.974949/full

Similar Items

Effects of Fuhe decoction on behaviors and monoamine neurotransmitters in different brain regions of CUMS combined with social isolation depression model rats
by: Ruoyun Zheng, et al.
Published: (2020-09-01)

Detection of Changes in Monoamine Neurotransmitters by the Neonicotinoid Pesticide Imidacloprid Using Mass Spectrometry
by: Anri Hirai, et al.
Published: (2022-11-01)

The High-Precision Liquid Chromatography with Electrochemical Detection (HPLC-ECD) for Monoamines Neurotransmitters and Their Metabolites: A Review
by: Bruno P. Guiard, et al.
Published: (2024-01-01)

Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology
by: Yunkwon Nam, et al.
Published: (2024-03-01)

The Effects of Unilateral Labyrinthectomy on Monoamine Neurotransmitters in the Medial Vestibular Nucleus of Rats
by: Jun Wang, et al.
Published: (2023-11-01)

Development and validation of a method for the quantitative determination of monoamine neurotransmitters and their metabolites in rat brain tissue using HPLC-MS/MS
by: A. L. Khokhlov, et al.
Published: (2024-03-01)

Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans
by: Meng-chen Wu, et al.
Published: (2023-10-01)

Editorial: Neurotransmitters and Emotions, Volume II
by: Fushun Wang, et al.
Published: (2022-05-01)

The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress
by: Trevor J. Buhr, et al.
Published: (2023-05-01)

Anti-Allergic and Anti-Inflammatory Effects of Neferine on RBL-2H3 Cells
by: Kuan-Ming Chiu, et al.
Published: (2021-10-01)

Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors
by: Tapan Behl, et al.
Published: (2021-06-01)

Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder
by: Patrick J. McCarty, et al.
Published: (2021-09-01)

Neferine inhibits the development of lung cancer cells by downregulating TGF‐β to regulate MST1/ROS‐induced pyroptosis
by: Peng‐Cheng Zhong, et al.
Published: (2023-11-01)

Tibetan mineral-herbal medicine Zuotai alleviates the depressive-like behaviors in chronic restraint-stressed mice while regulating stress hormone, inflammation and monoamine
by: Cen Li, et al.
Published: (2023-11-01)

Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters
by: Magdalena Kowalska, et al.
Published: (2021-06-01)

Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells
by: Onat Kadioglu, et al.
Published: (2017-05-01)

Chemosensitizing effect of neferine on cisplatin-resistant colorectal cancer: Identification of potential candidate genes and pathways through whole transcriptome profiling
by: Bharath Somasundram, et al.
Published: (2022-08-01)

Anti-Adipogenic Effect of Neferine in 3T3-L1 Cells and Primary White Adipocytes
by: Miey Park, et al.
Published: (2020-06-01)

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice
by: Chung-Chi Yang, et al.
Published: (2021-07-01)

Protective effect of neferine against UV-B-mediated oxidative damage in human epidermal keratinocytes
by: Abidullah Khan, et al.
Published: (2018-10-01)

Neferine inhibits the growth of human osteosarcoma cells through activating P38/JNK and suppressing Wnt/β-catenin signaling pathway
by: Jingtao Xu, et al.
Published: (2022-10-01)

Cinnamon oil solid self-microemulsion mediates chronic mild stress-induced depression in mice by modulating monoamine neurotransmitters, corticosterone, inflammation cytokines, and intestinal flora
by: Tianyu Ma, et al.
Published: (2023-06-01)

Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders
by: Yao Jiang, et al.
Published: (2022-09-01)

Research progress of non-monoamine antidepressants
by: Huan Zhang, et al.
Published: (2021-12-01)

Neferine Targets the Oncogenic Characteristics of Androgen-Dependent Prostate Cancer Cells via Inducing Reactive Oxygen Species
by: Subramanyam Dasari, et al.
Published: (2023-09-01)

Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway
by: Juan Li, et al.
Published: (2020-01-01)

Neferine, an Alkaloid from Lotus Seed Embryos, Exerts Antiseizure and Neuroprotective Effects in a Kainic Acid-Induced Seizure Model in Rats
by: Tzu-Yu Lin, et al.
Published: (2022-04-01)

Antidepressant-like activities of extracts of the fungus Paecilomyces tenuipes M98
by: Yaying Li, et al.
Published: (2019-10-01)

Optimization of Neferine Purification Based on Response Surface Methodology and Its Anti-Metastasis Mechanism on HepG2 Cells
by: Xinzhu Wang, et al.
Published: (2023-06-01)

Neferine ameliorates hypertensive vascular remodeling modulating multiple signaling pathways in spontaneously hypertensive rats
by: Weiquan Zeng, et al.
Published: (2023-02-01)

Carbon-Based Quantum Dots for Electrochemical Detection of Monoamine Neurotransmitters—Review
by: Saheed E. Elugoke, et al.
Published: (2020-10-01)

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3
by: Lukas Gebauer, et al.
Published: (2022-10-01)

Neurobiology of DOPA as a neurotransmitter /
by: Misu, Yoshimi, 1934-, et al.
Published: (2006)

Effect of neferine on diabetic nephropathy by regulating SDF-1/CXCR4 signal pathway
by: WANG Ying, et al.
Published: (2024-02-01)

Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems
by: Lisa Hahn, et al.
Published: (2024-01-01)

Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways
by: Chi-Ming Liu, et al.
Published: (2023-07-01)

A double‐blind, placebo‐controlled trial on the antihypertensive treatment effect of a quadruple single‐pill combination
by: Lei‐Xiao Hu, et al.
Published: (2021-04-01)

Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways
by: Shu-Rong Ma, et al.
Published: (2021-03-01)

Neferine inhibits Aβ1-42-induced PC12 cell injury through regulating the expression of miR-29a-3p/AQP4
by: ZENG Li-min, LU Zhao-hui, ZHOU Li-ping, ZHU Chao-xia
Published: (2020-01-01)

Comparison of Hypothalamic Monoamine Contents of Broiler- and Layer- Type Chickens at Prehatch and Posthatch
by: Izumi Yamasaki, et al.
Published: (2003-10-01)