Intrahepatic Cholestasis of Pregnancy Increases Inflammatory Susceptibility in Neonatal Offspring by Modulating Gut Microbiota

Intrahepatic Cholestasis of Pregnancy Increases Inflammatory Susceptibility in Neonatal Offspring by Modulating Gut Microbiota

Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that is characterized by increased bile acid levels in maternal serum. Studies have shown that cholestatic pregnancy can result in long-term metabolic disturbances in the offspring. However, how ICP shapes the offspring’s im...

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Bibliographic Details
Main Authors: Qiong-xi Lin, Wan-wen Huang, Wei Shen, Xiao-shi Deng, Zi-yu Tang, Zhen-hui Chen, Wei Zhao, Hong-ying Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
intrahepatic cholestasis of pregnancy
farnesoid X receptor
gut microbiota
bile acids
inflammation
immune function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.889646/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.889646/full

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