In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity

In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity

Summary: Thymus and spleen, in contrast to liver, are radiosensitive tissues in which p53-dependent apoptosis is triggered after whole-body radiation in vivo. Combined RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) analyses of radiation-treated mouse organs identifi...

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Bibliographic Details
Main Authors: Lois Resnick-Silverman, Royce Zhou, Moray J. Campbell, Ian Leibling, Ramon Parsons, James J. Manfredi
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002279

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http://www.sciencedirect.com/science/article/pii/S2211124723002279

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