Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System

Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System

Alzheimer's disease (AD) is a progressive neurodegenerative disease currently lacking effective treatment. Efficient delivery of siRNA via nanoparticles may emerge as a viable therapeutic approach to treat AD and other central nervous system disorders. We report here the use of a linear polyeth...

Full description

Bibliographic Details
Main Authors: Rishab Shyam, Yong Ren, Jason Lee, Kerstin E Braunstein, Hai-Quan Mao, Philip C Wong
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Alzheimer's disease
gene therapy
polymeric carriers
RNAi
siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300270

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116300270

Similar Items