Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature

Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature

Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake–promoting agouti related peptide (AgRP)/neuropeptide Y (NPY) neurons and a la...

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Bibliographic Details
Main Authors: Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-11-01
Series:JCI Insight
Subjects:
Endocrinology
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.162753

Internet

https://doi.org/10.1172/jci.insight.162753

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