DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

Abstract Background Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, and APOC1) are associated with cognitive function and dementia, particularly Alzheimer’s disease. Epigenetic mechanisms such as DNA methylation play a central role in the regulation of gene expressio...

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Bibliographic Details
Main Authors: Jiaxuan Liu, Wei Zhao, Erin B. Ware, Stephen T. Turner, Thomas H. Mosley, Jennifer A. Smith
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Medical Genomics
Subjects:
DNA methylation
Epigenetics
Cognition
Cognitive function
Delayed recall
Memory
Online Access:http://link.springer.com/article/10.1186/s12920-018-0363-9

Internet

http://link.springer.com/article/10.1186/s12920-018-0363-9

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