Reliable assessment of telomere maintenance mechanisms in neuroblastoma

Reliable assessment of telomere maintenance mechanisms in neuroblastoma

Abstract Background Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by activation of telomerase or alternative lengthening of telomeres (ALT). However, detection of TMM is not yet part of the clinical routine, and consensus on TMM detection, especia...

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Main Authors: Alina Meeser, Christoph Bartenhagen, Lisa Werr, Anna-Maria Hellmann, Yvonne Kahlert, Nadine Hemstedt, Peter Nürnberg, Janine Altmüller, Sandra Ackermann, Barbara Hero, Thorsten Simon, Martin Peifer, Matthias Fischer, Carolina Rosswog
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell & Bioscience
Subjects:
Neuroblastoma
Telomere maintenance
Alternative lengthening of telomeres
Telomerase
Online Access:https://doi.org/10.1186/s13578-022-00896-2

Internet

https://doi.org/10.1186/s13578-022-00896-2

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