Human Prolactin Point Mutations and Their Projected Effect on Vasoinhibin Generation and Vasoinhibin-Related Diseases

Human Prolactin Point Mutations and Their Projected Effect on Vasoinhibin Generation and Vasoinhibin-Related Diseases

BackgroundA dysregulation of the generation of vasoinhibin hormones by proteolytic cleavage of prolactin (PRL) has been brought into context with diabetic retinopathy, retinopathy of prematurity, preeclampsia, pregnancy-induced hypertension, and peripartum cardiomyopathy. Factors governing vasoinhib...

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Bibliographic Details
Main Authors: Jakob Triebel, Christin J. Friedrich, Andreas Leuchs, Gonzalo Martínez de la Escalera, Carmen Clapp, Thomas Bertsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Endocrinology
Subjects:
prolactin mutations
vasoinhibins
prolactin/vasoinhibin axis
peripartum cardiomyopathy
16 kDa prolactin
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00294/full

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http://journal.frontiersin.org/article/10.3389/fendo.2017.00294/full

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