U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression

U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression

Abstract Background Small nucleolar RNAs (snoRNAs) play key roles in ribosome biosynthesis. However, the mechanism by which snoRNAs regulate cancer stemness remains to be fully elucidated. Methods SNORA68 expression was evaluated in breast cancer tissues by in situ hybridization and qRT‒PCR. Prolife...

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Bibliographic Details
Main Authors: Wenrong Zhang, Xinyue Song, Zining Jin, Yiqi Zhang, Shan Li, Feng Jin, Ang Zheng
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
stemness
SNORA68
RPL23
Translocation to nucleolus
U2AF2
Online Access:https://doi.org/10.1186/s13058-024-01817-6

Internet

https://doi.org/10.1186/s13058-024-01817-6

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