Production of Cytotoxic Antibodies After Intra-Articular Injection of Allogeneic Synovial Membrane Mesenchymal Stem Cells With and Without LPS Administration

Production of Cytotoxic Antibodies After Intra-Articular Injection of Allogeneic Synovial Membrane Mesenchymal Stem Cells With and Without LPS Administration

Allogeneic mesenchymal stem cells (MSC) are widely used in clinical routine due to the shorter expansion time and reliability of its quality. However, some recipients can produce alloantibodies that recognize MSCs and activate the immune system, resulting in cell death. Although antibody production...

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Bibliographic Details
Main Authors: Gustavo dos Santos Rosa, André Massahiro Teramoto Krieck, Enrico Topan Padula, Fernanda de Castro Stievani, Mariana Correa Rossi, João Pedro Hübbe Pfeifer, Roberta Martins Basso, Aline Márcia Marques Braz, Márjorie de Assis Golim, Ana Liz Garcia Alves
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
humoral immune response
mesenchymal stromal cells
MHC
intraarticular injection
microcytotoxicity
cell rejection reactions
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.871216/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.871216/full

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