Exosomal miR-9-5p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence

Exosomal miR-9-5p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence

Abstract Doxorubicin (DOX) is a chemotherapeutic agent widely used for tumor treatment. Nonetheless its clinical application is heavily limited by its cardiotoxicity. There is accumulated evidence that transplantation of mesenchymal stem cell-derived exosomes (MSC-EXOs) can protect against Dox-induc...

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Bibliographic Details
Main Authors: Huifeng Zheng, Xiaoting Liang, Baojuan Liu, Xinran Huang, Ying Shen, Fang Lin, Jiaqi Chen, Xiaoyan Gao, Haiwei He, Weifeng Li, Bei Hu, Xin Li, Yuelin Zhang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
Exosomes
Mesenchymal stem cells
Doxorubicin
Cardiomyopathy
Senescence
Online Access:https://doi.org/10.1186/s12951-024-02421-8

Internet

https://doi.org/10.1186/s12951-024-02421-8

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