Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information led us to propose hybrids of TUB015 and nocod...

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Bibliographic Details
Main Authors: Marta Gargantilla, Leentje Persoons, Tereza Kauerová, Natalia del Río, Dirk Daelemans, Eva-María Priego, Peter Kollar, María-Jesús Pérez-Pérez
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
tubulin polymerization inhibitors
colchicine site
salicylanilides
niclosamide
signal transducer and activator of transcription (STAT3) inhibitors
Online Access:https://www.mdpi.com/1424-8247/15/7/835

Internet

https://www.mdpi.com/1424-8247/15/7/835

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