Fusion of a Novel Native Signal Peptide Enhanced the Secretion and Solubility of Bioactive Human Interferon Gamma Glycoproteins in Nicotiana benthamiana Using the Bamboo Mosaic Virus-Based Expression System

Fusion of a Novel Native Signal Peptide Enhanced the Secretion and Solubility of Bioactive Human Interferon Gamma Glycoproteins in Nicotiana benthamiana Using the Bamboo Mosaic Virus-Based Expression System

Plant viruses may serve as expression vectors for the efficient production of pharmaceutical proteins in plants. However, the downstream processing and post-translational modifications of the target proteins remain the major challenges. We have previously developed an expression system derived from...

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Bibliographic Details
Main Authors: Min-Chao Jiang, Chung-Chi Hu, Wei-Li Hsu, Tsui-Ling Hsu, Na-Sheng Lin, Yau-Heiu Hsu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Plant Science
Subjects:
interferon gamma
signal peptides
anti-virus activity
plant viral vector
glycosylation
Bamboo mosaic virus
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2020.594758/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2020.594758/full

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