Impaired B Cell Function in Mice Lacking Perforin-2

Impaired B Cell Function in Mice Lacking Perforin-2

Perforin-2 (P2) is a pore-forming protein with cytotoxic activity against intracellular bacterial pathogens. P2 knockout (P2KO) mice are unable to control infections and die from normally non-lethal bacterial infections. Here we show that P2KO mice as compared to WT mice show significantly higher le...

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Bibliographic Details
Main Authors: Daniela Frasca, Alain Diaz, Maria Romero, Thomas Vazquez, Natasa Strbo, Laura Romero, Ryan M. McCormack, Eckhard R. Podack, Bonnie B. Blomberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
splenic B cells
adipose tissue B cells
inflammation
perforin-2
antibody responses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00328/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00328/full

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