Evaluation of humoral immune responses of experimental animals to the recombinant SARS-CoV-2 spike ectodomain with the ISCOM adjuvant

Evaluation of humoral immune responses of experimental animals to the recombinant SARS-CoV-2 spike ectodomain with the ISCOM adjuvant

Scientific relevance. The use of recombinant antigens in vaccine production is limited because vaccines based on such antigens tend to have low immunogenicity. However, a COVID-19 vaccine that combines recombinant SARS-CoV-2 spike glycoprotein as its antigen and virus-like immune-stimulating complex...

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Bibliographic Details
Main Authors: V. A. Evseenko, A. V. Zaykovskaya, A. S. Gudymo, O. S. Taranov, S. E. Olkin, A. R. Imatdinov, E. Yu. Prudnikova, N. V. Danilchenko, I. S. Shulgina, M. N. Kosenko, E. I. Danilenko, S. A. Pyankov, A. B. Ryzhikov
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2023-12-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
virus-like immune-stimulating complex
iscom adjuvant
saponin
covid-19 vaccine
immunisation
sars-cov-2
recombinant antigen
spike glycoprotein
recombinant ectodomain
Online Access:https://www.biopreparations.ru/jour/article/view/523

Internet

https://www.biopreparations.ru/jour/article/view/523

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