Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari
Background and purpose: Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary ailment characterized by prolonged respiratory symptoms and airflow constriction. COPD stands as the third most prominent cause of mortality on a global scale. It is commonly linked to numerous extra-pulm...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-12-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-20058-en.pdf |
| _version_ | 1797377595862417408 |
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| author | Hossein Azadeh Maghsood Khalizadeh Seyed Hossein Mehravaran Masoud Aliyali Aref Hosseinian Amiri |
| author_facet | Hossein Azadeh Maghsood Khalizadeh Seyed Hossein Mehravaran Masoud Aliyali Aref Hosseinian Amiri |
| author_sort | Hossein Azadeh |
| collection | DOAJ |
| description | Background and purpose: Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary ailment characterized by prolonged respiratory symptoms and airflow constriction. COPD stands as the third most prominent cause of mortality on a global scale. It is commonly linked to numerous extra-pulmonary conditions, such as cardiopulmonary disorders, musculoskeletal frailty, and anemia. Osteoporosis, regarded as one of the principal systemic complications arising from COPD, represents an elevated susceptibility to osteoporotic fractures and imposes a significant financial burden. Considering the clinical significance surrounding the emphysema phenotype in COPD, as well as the lack of investigation on this matter in the country, the objective of this study is to determine the comparative prevalence of osteoporosis and osteopenia in COPD patients, with and without emphysema, who receive medical attention at Tubi Sari Clinic and Imam Khomeini Hospital in Sari.
Materials and methods: This cross-sectional study was conducted in 2021 on patients referred to the rheumatology and lung clinic, and COPD patients admitted to Imam Khomeini Hospital in Sari. In this study, 50 patients with COPD with emphysema as a case group and 50 patients with COPD without emphysema as a control group were included in the study. Then, using densitometry and examining the bone mass density of all COPD patients, the patients were divided into two groups: with and without osteoporosis. Then, the patient's information was entered into SPSS software and analyzed.
Results: There was no significant difference in vitamin D serum levels, vertebral fracture score, or BMD between emphysema and non-emphysema patients (P=0.09, P=0.098). Multivariate analysis showed that (in a model including age, BMI, FEV1, PaO2, emphysema score, CRP, and dyspnea score) only BMI, FEV1, and PaO2 decreased as independent risk factors for low BMD.
Conclusion: Our findings showed that emphysema is an independent risk factor for osteoporosis according to the multivariate model. Low BMI, severity of COPD, and hypoxia play a dominant role in the development of osteoporosis. |
| first_indexed | 2024-03-08T19:54:45Z |
| format | Article |
| id | doaj.art-04f7781234f7485da85ec0acb41c0924 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-08T19:54:45Z |
| publishDate | 2023-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-04f7781234f7485da85ec0acb41c09242023-12-24T06:57:31ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-12-01332277385Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in SariHossein Azadeh0Maghsood Khalizadeh1Seyed Hossein Mehravaran2Masoud Aliyali3Aref Hosseinian Amiri4 Assistant Professor, Department of Internal Medicine, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran Resident in Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Resident in Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary ailment characterized by prolonged respiratory symptoms and airflow constriction. COPD stands as the third most prominent cause of mortality on a global scale. It is commonly linked to numerous extra-pulmonary conditions, such as cardiopulmonary disorders, musculoskeletal frailty, and anemia. Osteoporosis, regarded as one of the principal systemic complications arising from COPD, represents an elevated susceptibility to osteoporotic fractures and imposes a significant financial burden. Considering the clinical significance surrounding the emphysema phenotype in COPD, as well as the lack of investigation on this matter in the country, the objective of this study is to determine the comparative prevalence of osteoporosis and osteopenia in COPD patients, with and without emphysema, who receive medical attention at Tubi Sari Clinic and Imam Khomeini Hospital in Sari. Materials and methods: This cross-sectional study was conducted in 2021 on patients referred to the rheumatology and lung clinic, and COPD patients admitted to Imam Khomeini Hospital in Sari. In this study, 50 patients with COPD with emphysema as a case group and 50 patients with COPD without emphysema as a control group were included in the study. Then, using densitometry and examining the bone mass density of all COPD patients, the patients were divided into two groups: with and without osteoporosis. Then, the patient's information was entered into SPSS software and analyzed. Results: There was no significant difference in vitamin D serum levels, vertebral fracture score, or BMD between emphysema and non-emphysema patients (P=0.09, P=0.098). Multivariate analysis showed that (in a model including age, BMI, FEV1, PaO2, emphysema score, CRP, and dyspnea score) only BMI, FEV1, and PaO2 decreased as independent risk factors for low BMD. Conclusion: Our findings showed that emphysema is an independent risk factor for osteoporosis according to the multivariate model. Low BMI, severity of COPD, and hypoxia play a dominant role in the development of osteoporosis.http://jmums.mazums.ac.ir/article-1-20058-en.pdfschool of medicinemazandaran university of medical sciencessariiran. |
| spellingShingle | Hossein Azadeh Maghsood Khalizadeh Seyed Hossein Mehravaran Masoud Aliyali Aref Hosseinian Amiri Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari Journal of Mazandaran University of Medical Sciences school of medicine mazandaran university of medical sciences sari iran. |
| title | Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari |
| title_full | Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari |
| title_fullStr | Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari |
| title_full_unstemmed | Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari |
| title_short | Comparison of the Frequency of Osteoporosis and Osteopenia in Patients with Chronic Obstructive Pulmonary Disease with and Without Emphysema in Sari |
| title_sort | comparison of the frequency of osteoporosis and osteopenia in patients with chronic obstructive pulmonary disease with and without emphysema in sari |
| topic | school of medicine mazandaran university of medical sciences sari iran. |
| url | http://jmums.mazums.ac.ir/article-1-20058-en.pdf |
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