Specific TCR profiles predict clinical outcome of adjuvant EGFR-TKIs for resected EGFR-mutant non-small cell lung cancer

Specific TCR profiles predict clinical outcome of adjuvant EGFR-TKIs for resected EGFR-mutant non-small cell lung cancer

Abstract Background ADJUVANT-CTONG1104 reported a favorable survival outcome from adjuvant gefitinib treatment over chemotherapy in EGFR-mutant non-small cell lung cancer (NSCLC) patients. However, heterogeneous benefit from EGFR-TKIs and chemotherapy demands further biomarker exploration for patien...

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Bibliographic Details
Main Authors: Si-Yang Maggie Liu, Cunte Chen, Yi-Kai Zhang, Wen-Zhao Zhong, Yi-Long Wu, Si-Yang Liu, Yangqiu Li
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biomarker Research
Subjects:
T-cell receptor repertoire
Vβ7-3Jβ2-5/Vβ24-1Jβ2-1/Vβ28Jβ2-2/Vβ5-6Jβ2-7
EGFR mutation
Adjuvant EGFR-TKI
Non-small cell lung cancer
CTONG1104
Online Access:https://doi.org/10.1186/s40364-023-00470-z

Internet

https://doi.org/10.1186/s40364-023-00470-z

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