Synthesis of quinoline attached-furan-2(3H)-ones having anti-inflammatory and antibacterial properties with reduced gastro-intestinal toxicity and lipid peroxidation

Synthesis of quinoline attached-furan-2(3H)-ones having anti-inflammatory and antibacterial properties with reduced gastro-intestinal toxicity and lipid peroxidation

A series of 3-[2-chloroquinolin-3-yl)methylene]-5-aryl-furan-2(3H)-ones {3(a-p)} were synthesized. The required 3-(substitutedbenzoyl) propionic acids {2(a-d)} were prepared under Friedal Craft acylation reaction conditions. The substituted 2-chloroquinoline-3-carbaldehydes {1(a-d)} were synthes...

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Bibliographic Details
Main Authors: Akhter Mymoona, Shaharyar M., Azam Faizul, Sarkar Priya Deba, Zaman M.S., Husain Asif, Marella Akranth, Alam Mohammad M., Alam Ozair
Format: Article
Language:English
Published: Serbian Chemical Society 2011-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
furanone
quinoline
anti-inflammatory
analgesic
antibacterial activity
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2011/0352-51391100142A.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0352-5139/2011/0352-51391100142A.pdf

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