CAVPENET Peptide Inhibits Prostate Cancer Cells Proliferation and Migration through PP1γ-Dependent Inhibition of AKT Signaling

CAVPENET Peptide Inhibits Prostate Cancer Cells Proliferation and Migration through PP1γ-Dependent Inhibition of AKT Signaling

Protein phosphatase 1 (PP1) complexes have emerged as promising targets for anticancer therapies. The ability of peptides to mimic PP1-docking motifs, and so modulate interactions with regulatory factors, has enabled the creation of highly selective modulators of PP1-dependent cellular processes tha...

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Bibliographic Details
Main Authors: Bárbara Matos, Antoniel A. S. Gomes, Raquel Bernardino, Marco G. Alves, John Howl, Carmen Jerónimo, Margarida Fardilha
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Pharmaceutics
Subjects:
prostate cancer
treatment
protein-protein interaction
protein phosphatase 1
PP1-targeting peptide
Online Access:https://www.mdpi.com/1999-4923/16/9/1199

Internet

https://www.mdpi.com/1999-4923/16/9/1199

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