Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis

Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid associated with nonalcoholic steatohepatitis (NASH). Immune cell-driven inflammation is a key determinant of NASH progression. Macrophages, monocytes, NK cells, T cells, NKT cells, and B cells variably express S1P receptors from a repertoire...

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Bibliographic Details
Main Authors: Chieh-Yu Liao, Fanta Barrow, Nanditha Venkatesan, Yasuhiko Nakao, Amy S. Mauer, Gavin Fredrickson, Myeong Jun Song, Tejasav S. Sehrawat, Debanjali Dasgupta, Rondell P. Graham, Xavier S. Revelo, Harmeet Malhi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
lipotoxicity
fatty liver
sphingolipids
Etrasimod
Amiselimod
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130184/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130184/full

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