Ketone Bodies Improve Human CD8+ Cytotoxic T-Cell Immune Response During COVID-19 Infection

Ketone Bodies Improve Human CD8+ Cytotoxic T-Cell Immune Response During COVID-19 Infection

Severe COVID-19 is characterized by profound CD8+ T-cell dysfunction, which cannot be specifically treated to date. We here investigate whether metabolic CD8+ T-cell reprogramming by ketone bodies could be a promising strategy to overcome the immunoparalysis in COVID-19 patients. This approach was t...

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Bibliographic Details
Main Authors: Simon Hirschberger, Luca Gellert, David Effinger, Maximilian Muenchhoff, Markus Herrmann, Josef-Maria Briegel, Bernhard Zwißler, Simone Kreth
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Medicine
Subjects:
Ketogenic Diet (KD)
SARS-CoV-2
COVID-19
T-cell immunometabolism
cytotoxic T cell
metabolic therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.923502/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.923502/full

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