Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights

Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights

Pancreatic ductal adenocarcinoma (PDAC) represents a great challenge to the successful delivery of the anticancer drugs. The intrinsic characteristics of the PDAC microenvironment and drugs resistance make it suitable for therapeutic approaches with stimulus-responsive drug delivery systems (DDSs),...

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Bibliographic Details
Main Authors: Rosa Maria Iacobazzi, Ilaria Arduino, Roberta Di Fonte, Angela Assunta Lopedota, Simona Serratì, Giuseppe Racaniello, Viviana Bruno, Valentino Laquintana, Byung-Chul Lee, Nicola Silvestris, Francesco Leonetti, Nunzio Denora, Letizia Porcelli, Amalia Azzariti
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
tumor microenvironment
drug resistance
drug delivery
controlled release
uPAR
Online Access:https://www.mdpi.com/2072-6694/14/1/5

Internet

https://www.mdpi.com/2072-6694/14/1/5

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