Costunolide Induces Autophagy and Apoptosis by Activating ROS/MAPK Signaling Pathways in Renal Cell Carcinoma

Costunolide Induces Autophagy and Apoptosis by Activating ROS/MAPK Signaling Pathways in Renal Cell Carcinoma

Although costunolide (Cos), a natural sesquiterpene compound isolated from various medicinal plants, exhibits antiproliferative and pro-apoptotic effects in diverse types of cancers, the mechanism associated with the anticancer property of Cos has not been elucidated. The present investigation was c...

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Bibliographic Details
Main Authors: Dian Fu, Ding Wu, Wen Cheng, Jianping Gao, Zhengyu Zhang, Jingping Ge, Wenquan Zhou, Zhenyu Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
costunolide
renal cancer
ROS – reactive oxygen species
apoptosis
autophage
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.582273/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.582273/full

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