AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells

AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells

Our team has previously reported a series of quinazoline-based lapatinib hybrids as potent kinase-targeting anticancer agents. Among them, AF8c showed a relatively safe profile in colorectal cancer (CRC) cells. In this study, we delineate a novel anticancer activity of AF8c in CRC cells. AF8c mediat...

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Bibliographic Details
Main Authors: Soyeon Jeong, Ahmed K. Farag, Hye Kyeong Yun, Yoon A. Jeong, Dae Yeong Kim, Min Jee Jo, Seong Hye Park, Bo Ram Kim, Jung Lim Kim, Bu Gyeom Kim, Dae-Hee Lee, Eun Joo Roh, Sang Cheul Oh
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
AF8c
colorectal cancer (CRC)
apoptosis
death receptors (DRs)
ER stress
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/2072-6694/14/13/3043

Internet

https://www.mdpi.com/2072-6694/14/13/3043

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