Mitochondrial dysfunction and consequences in calpain-3-deficient muscle

Mitochondrial dysfunction and consequences in calpain-3-deficient muscle

Abstract Background Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, sarcomere formation, and muscle cytoskeletal remodeling, the physiologi...

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Bibliographic Details
Main Authors: Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal, Kanneboyina Nagaraju
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Skeletal Muscle
Subjects:
LGMD2A
Mitochondria
Calpain-3 deficiency
Muscle membrane repair
Online Access:https://doi.org/10.1186/s13395-020-00254-1

Internet

https://doi.org/10.1186/s13395-020-00254-1

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