Haploinsufficiency of a Circadian Clock Gene <i>Bmal1</i> (<i>Arntl</i> or <i>Mop3</i>) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice

Haploinsufficiency of a Circadian Clock Gene <i>Bmal1</i> (<i>Arntl</i> or <i>Mop3</i>) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice

Approximately 50–80% of children with autism spectrum disorders (ASDs) exhibit sleep problems, but the contribution of circadian clock dysfunction to the development of ASDs remains largely unknown. The essential clock gene <i>Bmal1</i> (<i>Arntl</i> or <i>Mop3</i>...

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Bibliographic Details
Main Authors: Rubal Singla, Abhishek Mishra, Hao Lin, Ethan Lorsung, Nam Le, Su Tin, Victor X. Jin, Ruifeng Cao
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
clock gene
<i>Bmal1</i>
mTOR kinase
autism
mice
Online Access:https://www.mdpi.com/1422-0067/23/11/6317

Internet

https://www.mdpi.com/1422-0067/23/11/6317

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