Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model

Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model

Maternal hypothyroidism is associated with fetal growth restriction, placental dysfunction, and reduced kisspeptin/Kiss1R at the maternal-fetal interface. Kisspeptin affects trophoblastic migration and has antioxidant and immunomodulatory activities. This study aimed to evaluate the therapeutic pote...

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Bibliographic Details
Main Authors: Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Erikles Macedo Barbosa, Letícia Dias Mendonça, Emilly Oliveira Santos, Isabella Oliveira de Macedo, Mário Sergio Lima de Lavor, Raphael Escorsim Szawka, Rogeria Serakides, Juneo Freitas Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
kisspeptin
trophoblast
thyroid
cell stress
inflammation
fetal development
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.908240/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.908240/full

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