Image-Guided Analyses Reveal that Non-CD4 Splenocytes Contribute to CD4 T Cell–Mediated Inflammation Leading to Islet Destruction by Altering Their Local Function and Not Systemic Trafficking Patterns

Image-Guided Analyses Reveal that Non-CD4 Splenocytes Contribute to CD4 T Cell–Mediated Inflammation Leading to Islet Destruction by Altering Their Local Function and Not Systemic Trafficking Patterns

Recruitment of CD4 + T cells into islets is a critical component of islet inflammation (insulitis) leading to type 1 diabetes; therefore, determining if conditions used to treat diabetes change their trafficking patterns is relevant to the outcome. Cotransfer of CD4 + BDC2.5 (BDC) cells with non-CD4...

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Bibliographic Details
Main Authors: Mi-Heon Lee, Wen-Hui Lee, Yanghao Van, Christopher H. Contag, Chih-Pin Liu
Format: Article
Language:English
Published: SAGE Publications 2007-11-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2007.00033

Internet

https://doi.org/10.2310/7290.2007.00033

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