Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes

Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes

Therapies targeting the PD-L1/PD-1 axis have recently been introduced to triple-negative breast cancer (TNBC) with limited efficacy, suggesting that this axis promotes tumor progression through mechanisms other than immune suppression. Here, we over-expressed WT-PD-L1 in human TNBC cells (express en...

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Bibliographic Details
Main Authors: Nofar Erlichman, Tamir Baram, Tsipi Meshel, Dina Morein, Benny Da’adoosh, Adit Ben-Baruch
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
chemokines
CCR2
CCR5
CXCR1/2
luminal-A breast cancer
PD-1
Online Access:https://www.mdpi.com/2072-6694/14/4/1042

Internet

https://www.mdpi.com/2072-6694/14/4/1042

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