Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

<p>Abstract</p> <p>Background</p> <p>Huntington Disease (HD) is a neurodegenerative disorder in which caspase activation and cleavage of substrates, including the huntingtin protein, has been invoked as a pathological mechanism. Specific changes in caspase-2 (casp2) act...

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Bibliographic Details
Main Authors: Bissada Nagat, Deng Yu, Zhang Wei-Ning, Cao Li-Ping, Ehrnhoefer Dagmar E, Lerch Jason P, Graham Rona K, Southwell Amber L, Carroll Jeffrey B, Henkelman R, Hayden Michael R
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Molecular Neurodegeneration
Subjects:
Huntington's Disease
neurodegeneration
caspase
magnetic resonance imaging
Online Access:http://www.molecularneurodegeneration.com/content/6/1/59

Internet

http://www.molecularneurodegeneration.com/content/6/1/59

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