Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease
<p>Abstract</p> <p>Background</p> <p>Huntington Disease (HD) is a neurodegenerative disorder in which caspase activation and cleavage of substrates, including the huntingtin protein, has been invoked as a pathological mechanism. Specific changes in caspase-2 (casp2) act...
Main Authors: | Bissada Nagat, Deng Yu, Zhang Wei-Ning, Cao Li-Ping, Ehrnhoefer Dagmar E, Lerch Jason P, Graham Rona K, Southwell Amber L, Carroll Jeffrey B, Henkelman R, Hayden Michael R |
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Format: | Article |
Language: | English |
Published: |
BMC
2011-08-01
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Series: | Molecular Neurodegeneration |
Subjects: | |
Online Access: | http://www.molecularneurodegeneration.com/content/6/1/59 |
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