Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers

Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers

Immune checkpoint inhibitors (CPIs) represent an effective therapeutic strategy for several different types of solid tumors and are remarkably effective in mismatch repair deficient (MMRd) tumors, including colorectal cancer (CRC). The prevalent view is that the elevated and dynamic neoantigen burde...

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Bibliographic Details
Main Authors: Vito Amodio, Gianluca Mauri, Nicole M. Reilly, Andrea Sartore-Bianchi, Salvatore Siena, Alberto Bardelli, Giovanni Germano
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
colorectal cancer
mismatch repair deficiency
MSI
microsatellite instability
immune escape
immune surveillance
Online Access:https://www.mdpi.com/2072-6694/13/11/2638

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https://www.mdpi.com/2072-6694/13/11/2638

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