Traditional Chinese decoction Si Zhi Wan attenuates ovariectomy (OVX)-induced bone loss by inhibiting osteoclastogenesis and promoting apoptosis of mature osteoclasts

Traditional Chinese decoction Si Zhi Wan attenuates ovariectomy (OVX)-induced bone loss by inhibiting osteoclastogenesis and promoting apoptosis of mature osteoclasts

Si Zhi Wan (SZW) is a traditional Chinese decoction used for osteoporosis treatment. Currently, the effect of SZW on ovariectomy (OVX)-induced bone loss and the underlying mechanisms remain unknown. Herein, we investigated the therapeutic effect of SZW on osteoporosis and explored the underlying mec...

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Bibliographic Details
Main Authors: Qingman He, Kanghua Fu, Huan Yao, Shujun Wei, Li Xiang, Sixian Liu, Tao Chen, Yongxiang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Si Zhi Wan
traditional Chinese decoction
osteoclastogenesis
apoptosis
NF-κB signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.983884/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.983884/full

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