Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis

Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis

Abstract Background Osteoarthritis (OA) is a degenerative joint disease with lacking effective prevention targets. A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) is a member of the ADAMTS family and is upregulated in OA pathologic tissues with no fully understood molecu...

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Bibliographic Details
Main Authors: Shu Yang, Xuanping Zhou, Zhen Jia, Mali Zhang, Minghao Yuan, Yizhao Zhou, Jing Wang, Duo Xia
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Medicine
Subjects:
Osteoarthritis
Inflammation
ADAMTS12
STAT1
METTL3
IGF2BP2
Online Access:https://doi.org/10.1186/s10020-023-00661-2

Internet

https://doi.org/10.1186/s10020-023-00661-2

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