Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer

Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer

Successful development of immunotherapeutic strategies for hepatocellular cancer (HCC) has been impeded by limited understanding of tumor-induced profound tolerance and lack of a clinically faithful HCC model. Recently, we developed a novel model that recapitulates typical features of human HCC. Usi...

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Bibliographic Details
Main Authors: Dai Liu, Guangfu Li, Diego M. Avella, Eric T. Kimchi, Jussuf T. Kaifi, Mark P. Rubinstein, E. Ramsay Camp, Don C. Rockey, Todd D. Schell, Kevin F. Staveley-O'Carroll
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
hepatocellular cancer (hcc)
sunitinib
immunotolerance
immunotherapy
regulatory t cell (treg)
murine model
cd8+ t cells
ifn-γ
tnf-α
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1372079

Internet

http://dx.doi.org/10.1080/2162402X.2017.1372079

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