Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers.

INTRODUCTION: In vivo pH imaging has been a field of interest for molecular imaging for many years. This is especially important for determining tumor acidity, an important driving force of tumor invasion and metastasis formation, but also in the process of apoptosis. METHODS: 2-(4-[(123)I]iodophene...

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Bibliographic Details
Main Authors: Matthias Bauwens, Marijke De Saint-Hubert, Jan Cleynhens, Laura Brams, Ellen Devos, Felix M Mottaghy, Alfons Verbruggen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3374791?pdf=render