The Proteasome Inhibitor MG-132 Protects Hypoxic SiHa Cervical Carcinoma Cells after Cyclic Hypoxia/Reoxygenation from Ionizing Radiation

The Proteasome Inhibitor MG-132 Protects Hypoxic SiHa Cervical Carcinoma Cells after Cyclic Hypoxia/Reoxygenation from Ionizing Radiation

INTRODUCTION: Transient hypoxia and subsequent reoxygenation are common phenomena in solid tumors that greatly influence the outcome of radiation therapy. This study was designed to determine how varying cycles of hypoxia/reoxygenation affect the response of cervical carcinoma cells irradiated under...

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Bibliographic Details
Main Authors: Frank Pajonk, Thorsten Grumann, William H. McBride
Format: Article
Language:English
Published: Elsevier 2006-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Reoxygenation
hypoxia
radiation response
MG-132
26S proteasome
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606801090

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http://www.sciencedirect.com/science/article/pii/S1476558606801090

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