Construction of BHV-1 UL41 Defective Virus Using the CRISPR/Cas9 System and Analysis of Viral Replication Properties

Construction of BHV-1 UL41 Defective Virus Using the CRISPR/Cas9 System and Analysis of Viral Replication Properties

Bovine herpesvirus type 1 (BHV-1) is a neurotropic herpesvirus that causes infectious rhinotracheitis and vulvovaginitis in cattle. The virion host shutoff protein encoded by the BHV-1 UL41 gene is highly conserved in the Alphaherpesvirinae subfamily. This protein can degrade viral and host messenge...

Full description

Bibliographic Details
Main Authors: Haiyue Dai, Jianan Wu, Hongshu Yang, Yongli Guo, Haoqing Di, Mingchun Gao, Junwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
BHV-1
UL41
CRISPR/Cas9
defective virus
replications
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.942987/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.942987/full

Similar Items