NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1β-mediated neuroinflammation

NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1β-mediated neuroinflammation

Abstract Background Patients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies suggested that NLRP3 inflammasome played an important role in the pathophysiology of heat stroke. Methods In this study, we used a classic animal...

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Bibliographic Details
Main Authors: Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li, Guo-Bao Li
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
NLRP3 inflammasome
Heatstroke
Neuroinflammation
IL-1β
Online Access:https://doi.org/10.1186/s12974-021-02179-y

Internet

https://doi.org/10.1186/s12974-021-02179-y

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