PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis

PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis

Summary: Myofibroblasts are responsible for scarring during fibrosis. The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell state and increasing profibrotic phenotype. Here, we show mechanical stress from progressive scarring induces nuclear softening and de-...

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Bibliographic Details
Main Authors: Elliot Jokl, Aoibheann F. Mullan, Kara Simpson, Lindsay Birchall, Laurence Pearmain, Katherine Martin, James Pritchett, Sayyid Raza, Rajesh Shah, Nigel W. Hodson, Craig J. Williams, Elizabeth Camacho, Leo Zeef, Ian Donaldson, Varinder S. Athwal, Neil A. Hanley, Karen Piper Hanley
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014262

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http://www.sciencedirect.com/science/article/pii/S2211124723014262

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