Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host

Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host

Abstract Shiga toxins (Stxs) produced by enterohemorrhagic Escherichia coli (EHEC) are the major virulence factors responsible for hemorrhagic colitis, which can lead to life‐threatening systemic complications including acute renal failure (hemolytic uremic syndrome) and neuropathy. Here, we report...

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Bibliographic Details
Main Authors: Kyung‐Soo Lee, Jieun Lee, Pureum Lee, Bong Chan Jeon, Min Yeong Song, Sojung Kwak, Jungwoon Lee, Jun‐Seob Kim, Doo‐Jin Kim, Ji Hyung Kim, Vernon L Tesh, Moo‐Seung Lee, Sung‐Kyun Park
Format: Article
Language:English
Published: Springer Nature 2022-01-01
Series:EMBO Molecular Medicine
Subjects:
apoptosis
hemolytic uremic syndrome
inflammation
O‐GlcNAcylation
Shiga toxin
Online Access:https://doi.org/10.15252/emmm.202114678

Internet

https://doi.org/10.15252/emmm.202114678

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